Uteroglobin-related protein 1 and severity of inhalation injury
نویسندگان
چکیده
منابع مشابه
Uteroglobin-related protein 1 and severity of inhalation injury
Introduction Burns are a major global public health problem. It is estimated that over 300 million burn victims die each year worldwide. Most accidents are domestic or on workplace and involve mainly women and children. With the advances made in the care of burned patients, the mortality has decreased in recent years and the inhalation injury has become the leading cause of death in these patie...
متن کاملDecreased expression of uteroglobin-related protein 1 in inflamed mouse airways is mediated by IL-9.
Uteroglobin-related protein 1 (UGRP1) is a secretory protein, highly expressed in epithelial cells of airways. Although an involvement of UGRP1 in the pathogenesis of asthma has been suggested, its function in airways remains unclear. In the present study, a relationship between airway inflammation, UGRP1 expression, and interleukin-9 (IL-9), an asthma candidate gene, was evaluated by using a m...
متن کاملExpression of high in normal-1 (HIN-1) and uteroglobin related protein-1 (UGRP-1) in adult and developing tissues
We analyzed the expression of high in normal-1 (HIN-1), a putative breast tumor suppressor gene, and uteroglobin related protein-1 (UGRP-1), a homologue of HIN-1, in adult and developing mouse tissues. Highest HIN-1 and UGRP-1 expression is detected in the lung, while lower level HIN-1 expression is also detected in the stomach, heart, small intestine, uterine and mammary glands. The expression...
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The dose responsiveness of selected physiologic indices was studied in a sheep model of smoke inhalation injury. In this model, graded severity of injury was achieved by changing the contact time with smoke (defined by "unit"), whereas other variables were kept constant. Blood gas and cardiopulmonary indices were measured in 70 sheep, including 12 controls, either 24 or 72 hours after exposure ...
متن کاملUteroglobin-related protein 1 gene -112G/a polymorphism and atopic asthma in Sicilian children.
The secretory protein, uteroglobin-related protein 1 (UGRP1), is expressed mainly in the lung and trachea and recently has been implicated in asthma. The -112G to A transition in the promoter was reported to be associated with asthma in the Japanese population. However, this has not been replicated in other studies. The aim of this study was to find the association of the UGRP1 gene polymorphis...
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ژورنال
عنوان ژورنال: Intensive Care Medicine Experimental
سال: 2015
ISSN: 2197-425X
DOI: 10.1186/2197-425x-3-s1-a320